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Chlorphenesin
Maolate
氯苯甘醚

分子式:C9H11ClO3 分子量:202.63 Cas No:104-29-0
防腐剂、杀菌剂,对皮肤有产生过敏反应的可能性[1][2]。
[1] Brown R (1981). "Chlorphenesin sensitivity". Contact Dermatitis 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118.
[2] Burns DA (1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis 14 (33): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223.
Chemical formula
c
2012-06-11
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化妆品防腐剂成分使用基准表
94年6月1日卫署药字第0940306890号公告增列
Chlorphenesin 0.3%

2017-07-06
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Molecular Weight
202.6359
https://chem.nlm.nih.gov/chemidplus/rn/104-29-0

n
2020-06-01
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May cause skin irritation and allergic dermatitis, which was reported in multiple human case studies from an article published by Cosmetic Ingredient Review in 2020 (EWG.org).

2020-07-01
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Chlorphenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group.
It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections.
Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.
It has a role as a muscle relaxant, an antibacterial drug and an antifungal drug. It is a glycol, a member of propane-1,2-diols and a member of monochlorobenzenes.

氯酚素是其中一个伯羟基之一的氢被4-氯苯基取代的甘油。
它具有抗真菌和抗菌性能,可用于治疗皮肤和阴道感染。
它的1个氨基甲酸酯用作骨骼肌松弛剂,可治疗疼痛的肌肉痉挛。
它具有肌肉放松剂,抗菌药和抗真菌药的作用。
它是乙二醇,丙烷1,2-二醇的成员和一氯苯的成员。

https://pubchem.ncbi.nlm.nih.gov/compound/Chlorphenesin

2020-07-22
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可安全用于化妆品和个人护理产品。
CIR专家小组审查了表明通过皮肤吸收的数据,吸收速率小于该化合物的代谢和排泄速率。
因此,皮肤接触后氯霉素的血浆浓度将保持较低水平。CIR专家小组还审查了表明没有遗传毒性或发育毒性的数据,也不是皮肤刺激剂或敏化剂。
根据现有数据,CIR专家小组得出结论,可以安全地用于化妆品和个人护理产品中。
在欧盟可以以0.3%的最大浓度用作化妆品和个人护理产品中的防腐剂。

https://cosmeticsinfo.org/ingredient/chlorphenesin

2020-07-22
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Chlorphenesin is prepared by condensing equimolar amounts of p-chlorophenol and glycidol in the presence of a tertiary amine or a quaternary ammonium salt as a catalyst.3

通过叔胺或季铵盐作为催化剂,将等摩尔量的对氯苯酚和缩水甘油缩合来制得氯苯甘醚。

https://www.cir-safety.org/sites/default/files/Chlorp092012rep.pdf

Z
2021-04-14
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Chlorphenesin is a preservative, widely used in cosmetics and compatible with most preservatives (including potassium sorbate, sodium benzoate and methyl isothiazolinone).

https://www.zleyholdings.com/products/104-29-0

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