The Human and Environmental Risk Assessment (HERA) project performed a thorough investigation of all alkyl sulfates, as such the results they found apply directly to ALS. Most alkyl sulfates exhibit low acute oral toxicity, no toxicity through exposure to the skin, concentration dependent skin irritation, and concentration dependent eye-irritation. They do not sensitize the skin and did not appear to be carcinogenic in a two year study on rats. The report found that longer carbon chains (16–18) were less irritating to the skin than chains of 12–15 carbons in length. In addition, concentrations below 1% were essentially non-irritating while concentrations greater than 10% produced moderate to strong irritation of the skin.