Methylparaben
Methyl Paraben, Methyl Parahydroxybenzoate, Methyl p-hydroxybenzoate, Nipagin M, Methyl Hydroxybenzoate, Methyl 4-hydroxybenzoate
Formula: C8H8O3 Molecular Weight: 152.15 Cas No:99-76-3
Fragrance; Antimicrobial; Preservative, antifungal agent commonly used in cosmetics.

Controversy about the safety of Parabens, including Methylparaben, has been ongoing, but according to FDA data, Parabens are generally regarded as safe (GRAS) ingredients [1]. In fact, these ingredients are naturally present in fruits like blueberries.

Methylparaben is easily absorbed by the stomach and skin, but is also hydrolyzed in the body to p-hydroxybenzoic acid, which is then rapidly excreted in the urine. Basically, this ingredient is not irritating or sensitizing to healthy skin, but there have been cases of allergic reactions in the past [2].

Studies have shown that Methylparaben may react with UVB rays on the skin, thereby increasing the risk of skin aging[3][4].
[1] Parabens, Food and Drug Administration.
[2] Soni MG, Taylor SL, Greenberg NA, Burdock GA (October 2002). "Evaluation of the health aspects of methyl paraben: a review of the published literature". Food Chem. Toxicol. 40 (10): 1335–73. doi:10.1016/S0278-6915(02)00107-2 . PMID 12387298.
[3] Handa, O; Kokura, S; Adachi, S; Takagi, T; Naito, Y; Tanigawa, T; Yoshida, N; Yoshikawa, T (2006). "Methylparaben potentiates UV-induced damage of skin keratinocytes". Toxicology 227 (1–2): 62–72. doi:10.1016/j.tox.2006.07.018 . PMID 16938376.
[4] Okamoto, Yoshinori; Hayashi, Tomohiro; Matsunami, Shinpei; Ueda, Koji; Kojima, Nakao (2008). "Combined Activation of Methyl Paraben by Light Irradiation and Esterase Metabolism toward Oxidative DNA Damage". Chemical Research in Toxicology 21 (8): 1594–9. doi:10.1021/tx800066u . PMID 18656963.
Chemical formula
J
2011-09-11
people liked

請問methylparaben 等同methylchorisithiazinoline/methylisothiazionlone?
我對 methylchorisithiazinoline/methylisothiazionlone有高度敏感,是否不能用有methylparaben 成份的化妝品及護膚產品?

h
2012-05-16
people liked

中国化妆品卫生规范中规定对羟基苯甲酸酯类防腐剂在化妆品中单一酯的最高限量为0.4%,混合酯为0.8%。有研究报道化妆品中过量使用对羟基苯甲酸酯可引起接触性皮炎。,由于尼泊金酯的添加量只有山梨酸、苯甲酸的1/ 10~1/ 5 ,因此其相对安全性比山梨酸高得多。---------可是为什么薇姿等敏感皮肤用都写不含尼泊金酯类防腐剂?

h
2012-05-16
people liked

蜂王浆含多种氨基酸成分:氨基酸约占蜂王浆干重的1.8%,人体中所需要的8种必需氨基酸,在蜂王浆中都有存在,其中脯氨酸含量最高约占63%,目前在蜂王浆中已找到20种氨基酸。

2012-10-19
people liked

大家看看这篇博文,可能我们真是把paraben防腐剂的毒性太放大了:http://blog.sina.com.cn/s/blog_6c2cbf740102dt9o.html

z
2012-10-28
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我用的一款化妆水含有这个成分,用了很久有没有事阿?

x
2013-09-14
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http://www.fancl-hk.com/announcement/product_safety_201109.asp?Type=I

j
2014-02-15
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“防腐劑,不適合與胺基酸類(amines)成份共同使用”
這是沒有根據的,邏輯上更是講不通
如果是這樣:那我請問皮膚沒有氨基酸嗎?還用等到配方
進皮膚不就完了,氨基酸一堆在等它反應。
PARABEN是全世界公認最安全的防腐劑之一
張麗卿早期出道的時候,發表很多言論都有問題,後來她也做更正了。要注意引用。

藥物化學博士
Jack Lai,Ph.D.

a
2014-08-23
people liked

今天檢視了-Kiehl's 金盞花植物化妝水 亦含此成份。

a
2014-08-23
people liked

個人調製 DIY 保養品 時,曾試放 入 M.P, P.P.防腐 抗菌…,但 有 試用者 反應→ 會有 一會兒 的 刺灼感~。

因同配方調製出的東西,前一次調的沒有加。

(當然放入的含量有按指示劑量!)

j
2015-05-28
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意思是用这个成份需要适当防晒么

t
2018-09-12
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「化粧品中防腐劑成分使用及限量規定基準表」(衛授食字第1051611716號) :
(a) 0.4% (以 acid 計,單獨使用)
(b) 0.8% (以 acid 計,混合使用)
(非立即沖洗掉之產品,不得使用於三歲以下孩童之尿布部位)

https://www.fda.gov.tw/tc/newsContent.aspx?id=21796&chk=afa47e78-8256-4b40-b00f-2bb9998295d0

S
2019-12-16
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森田药妆面膜含有此成分,但是不知道超不超标,能用吧?

C
2020-04-04
people liked

---------可是为什么薇姿等敏感皮肤用都写不含尼泊金酯类防腐剂?
这样写会让人觉得很安全~
大众习惯盯着不含2个字看了~
包括有些配方,本就不需要添加酒精,然后写一个 不含酒精.

2021-03-09
people liked

Main benefits: Prevents fungus growth, preserves ingredients, creates antibacterial formulas. Who should use it: It is recommended for all skin types except sensitive, allergic, and/or eczematous skin. How often can you use it: Methylparaben is found in many daytime and nighttime products.25 Feb 2020

https://www.byrdie.com/methylparaben-for-skin-4779820

5
2021-05-05
people liked

强调健康肌肤无感。
敏感,痘肌,伤口,屏障脆弱都属不健康肌肤。
产品宣传是一种营销手段,还是具体看产品成分甚至要到药监局网站确认其成分的抽检报告。

n
2021-05-18
people liked

There is controversy about whether methylparaben or propylparabens are harmful at concentrations typically used in body care or cosmetics. Methylparaben and propylparaben are considered generally recognized as safe (GRAS) by the USFDA for food and cosmetic antibacterial preservation.
关于对羟基苯甲酸甲酯或者对羟基苯甲酸丙酯在身体护理和化妆品的典型添加浓度下,是否有害,一直争议不断。美国食品药品管理局认为它们作为食品和化妆品的抗菌保鲜剂,一般是安全的。

Methylparaben is readily metabolized by common soil bacteria, making it completely biodegradable.
对羟基苯甲酸甲酯可被常见的土壤细菌稳定代谢,使它完全可生物降解。

Methylparaben is readily absorbed from the gastrointestinal tract or through the skin. It is hydrolyzed to p-hydroxybenzoic acid and rapidly excreted in urine without accumulating in the body.
对羟基苯甲酸甲酯可以从肠胃道或皮肤稳定吸收。它可以水解成对羟基苯甲酸,随尿液迅速排泄,在身体中不会富集。
Acute toxicity studies have shown that methylparaben is practically non-toxic by both oral and parenteral administration in animals.
急性毒性研究显示,对羟基苯甲酸甲酯对动物口服和肠胃外给药,实际上没有毒性。
In a population with normal skin, methylparaben is practically non-irritating and non-sensitizing; however, allergic reactions to ingested parabens have been reported.
对于普通皮肤的人群,对羟基苯甲酸甲酯实际上无刺激性,也不会致敏。然而,摄取对羟基苯甲酸酯导致的过敏反应曾有报道。
A 2008 study found no competitive binding for human estrogen and androgen receptors for methylparaben, but varying levels of competitive binding were seen with butyl- and isobutyl-paraben.
一个2008年的研究发现,对羟基苯甲酸甲酯对人类雌激素和雄激素的受体没有竞争性结合力,但羟基苯甲酸正丁酯和对羟基苯甲酸异丁酯的竞争性结合力水平有别。
Studies indicate that methylparaben applied on the skin may react with UVB, leading to increased skin aging and DNA damage.
研究表明,对羟基苯甲酸甲酯涂在皮肤上会和B段紫外线反应,导致皮肤老化和DNA损伤的加剧。

y
2022-03-10
people liked

甲乙酯在规定范围内基本没事,甲酯在国内还用于食物防腐。

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