Octinoxate
Octylmethoxy Cinnamate, Octyl Methoxycinnamate, Ethylhexyl methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate, 2-Ethylhexyl-p-methoxycinnamate, Parsol MCX, Escalol 557, Eusolex 2292, Uvinul 3088, Tinosorb OMC
桂皮酸盐, 4-甲氧基肉桂酸-2-乙基己基酯, 甲氧基肉桂酸辛酯, 2-羟基-4-甲氧基二苯甲酮, 甲氧基肉桂酸乙基己酯
分子式:C18H26O3 分子量:290.4 Cas No:5466-77-3
光稳定剂、紫外线吸收剂、紫外线过滤剂,可以阻隔 UVB 290-320,为防晒成份,目前全世界被广为採用的化学防晒成份。卫生署限量10%。

防晒成份,油性化学性紫外线吸收剂,危险指数为 2/5(越高越不好)[1]。
[1] 张丽卿,『优质保养品选择策略』,联经出版社,2003/07/10。
Chemical formula
s
2008-12-04
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刺激性高吗?
最少可加多少%?

s
2008-12-04
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刺激性高吗?
最高可加多少%?

2009-08-14
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最高只可到10% ,刺激性算低 ,

在防晒产品中很常见

b
2010-02-28
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日文:
メトキシケイヒ酸エチルヘキシル、
メトキシケイヒ酸オクチル、
パラメトキシケイ皮酸2-エチルヘキシル,
參見:http://www.ba-m-bi.com/seibun/gaiyo/metokisi.htm

a
2010-06-06
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对皮肤的刺激性小,但在动物试验中观察到其对雌激素有所影响,浓度限量10%。

y
2012-10-16
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干扰正常内分泌。

r
2013-06-06
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请问它的危险体现在哪里

y
2014-01-15
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Extensive research has shown that a number of UV filters frequently used in the formulation of commercial sunscreens, such as 4 MBC, octyl methoxycinnamate, oxybenzone (benzophenone-3), octyl-dimethyl-PABA and octinoxate, possess endocrine activity. Endocrine disruptors are chemicals that interfere with endogenous hormone action and/or production. These have been implicated in the development of a number of diseases in both males and females, including cancer of the mammary glands and reproductive organs, as well as the abnormal development of the male reproductive system. In one study, the application of three active ingredients commonly found in sunscreens (oxybenzone, 4-MBC and octinoxate) for one week led to a drop in testosterone and estradiol levels in men. More worrying is that these chemicals have been found in breast milk at concentrations known to have oestrogenic effects.

s
2015-08-16
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这个成分晚上涂了会堵塞毛孔吗?

d
2016-05-25
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这个成分是皮肤炎的过敏原之一,不适合敏感肌用

o
2016-06-12
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同关心,为什么这个长期危险性评分为6这么高?【我自己就长期使用这款产品....

r
2016-06-24
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桂皮酸盐(octinoxate)会导致男性体内睪固酮下降。

r
2016-06-30
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一个或多个人类病例研究表明可能有光敏性或过敏作用
一个或多个动物的研究表明在高剂量有发展的影响
一个或多个动物的研究表明在高剂量有生殖的影响
一个或多个动物的研究表明在高剂量有肝脏的影响

m
2016-09-23
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不建议使用的物质

h
2016-11-26
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在安全浓度限量內使用安全?

t
2016-12-22
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甲氧基肉桂酸辛酯 (Octinoxate)
作用是以吸收阳光中的中波紫外线(UVB),保护皮肤免于其伤害,是目前最常广泛使用的 UVB 防晒乳。甲氧基肉桂酸辛酯对皮肤刺激性小,但却会扰乱荷尔蒙、造成皮肤老化,并产生自由基破坏皮肤细胞。
http://news.everydayhealth.com.tw/2015/06/25/5773-%E8%81%B0%E6%98%8E%E6%8C%91%E9%81%B8%EF%BC%816%E7%A8%AE%E9%98%B2%E6%9B%AC%E4%B9%B3%E5%8D%B1%E9%9A%AA%E6%88%90%E5%88%86%E5%A4%A7%E5%89%96%E6%9E%90

j
2017-05-31
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即便在低剂量的情况下,会刺激珊瑚的共生藻体内的病毒攻击共生藻,间接使珊瑚白化甚至死亡,而共生藻死亡后的病毒被释入海水后,导致周边海水病毒浓度增加,提高了其他珊瑚体内共生藻的感染率。

资料来源:环境资讯中心TEIA

2018-07-17
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Regarding safety, there are also some concerns around Octinoxate. In vitro (made in the lab not on real people) and animal studies have shown that it may produce hormonal (estrogen-like) effects. Do not panic, the studies were not conducted under real life conditions on real human people, so it is probably over-cautious to avoid Octinoxate altogether. However, if you are pregnant or a small child (under 2 yrs. old), choose a physical (zinc oxide/titanium dioxide) or new-generation Tinosorb based sunscreen, just to be on the super-safe side. :)

Overall, Ethylhexyl Methoxycinnamate is an old-school chemical sunscreen agent. There are plenty of better options for sun protection today, but it is considered "safe as used" (and sunscreens are pretty well regulated) and it is available worldwide (can be used up to 10% in the EU and up to 7.5% in the US).
https://incidecoder.com/ingredients/ethylhexyl-methoxycinnamate

2019-04-16
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https://www.medpartner.club/wp-content/uploads/2017/07/%E9%98%B2%E6%9B%AC%E7%B3%BB%E5%88%975_%E8%A1%A8%E6%A0%BC.png

2019-04-16
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美的好朋友制作的表格

a
2019-09-01
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Banned in Hawaii

s
2020-02-13
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桂皮酸盐是常见的防晒剂,全世界通用
由肉桂树皮所提炼的成分

有少数研究指出,对贺尔蒙有影响,但相关证实还不足够
所以对孕妇或幼儿少用较佳

f
2020-09-04
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润唇膏上有此成分,吃到会怎样吗?Dior的粉漾润唇膏

2021-04-13
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Fast facts
Approved in: Certain U.S. states, Europe, Japan, Australia
Banned in: Hawaii, Key West (Florida), Palau
Best for: Sunburn prevention
Coral safe? No, may also potentially affect fish

Found in chemical sunscreens

Octinoxate is a common and potent UVB absorber, meaning it’s effective for sun damage prevention. Combined with avobenzone, they can both provide great broad-spectrum protection against burns and aging.

This ingredient is allowed in formulations (up to 7.5 percent), but is banned in Hawaii due to the environmental risks on coral reefs.

https://www.healthline.com/health/beauty-skin-care/best-sunscreen-ingredients#octinoxate

k
2021-07-07
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这个成分是海洋杀手,拜託大家去海边玩尽量不要选有这个成分的防晒

C
2022-04-19
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Not coral reefs and marine life friendly! Belongs to the HEL list of ingredients to avoid while purchasing SPF to protect the marine environment:

The HEL LIST includes:

Any form of microplastic sphere or beads.
Any nanoparticles like zinc oxide or titanium dioxide.
Oxybenzone
Octinoxate
4-methylbenzylidene camphor
Octocrylene
Para-aminobenzoic acid (PABA)
Methyl Paraben
Ethyl Paraben
Propyl Paraben
Butyl Paraben
Benzyl Paraben
Triclosan
(Source: https://haereticus-lab.org/protect-land-sea-certification-3/)

P
2022-06-15
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对海洋环境不友好

2022-07-04
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甲氧基肉桂酸乙基己酯、桂皮酸盐

a
2023-07-01
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Octinoxate, also called Octyl methoxycinnamate or (OMC), is a UV filter. It can be absorbed rapidly through skin. Octinoxate has been detected in human urine, blood and breast milk, which indicates that humans are systemically exposed to this compound. [1],[2] Octinoxate is an endocrine disruptor that mimics estrogen and can disrupt thyroid function.

*WHAT IS OCTINOXATE?

Octinoxate filters UV-B rays from the sun. It does not protect against UV-A rays. Octinoxate dissolves in oil, which makes it a fat-seeking substance in the body. It is formed by combining methoxycinnamic acid and 2-ethylhexanol- compounds which are not harmful on their own. When mixed together, they form a clear liquid that does not dissolve in water. It is found in hair color products and shampoos, sunscreen, lipstick, nail polish, and skin creams. [5] In products other than sunscreens, it is used as a UV filter to protect the products from degrading when exposed to the sun.

*Health Concerns

>Endocrine disruption:
Octinoxate increases cell proliferation in cells that grow in response to estrogen exposure. [2],[6],[7] Lifetime estrogen exposure is an established risk factor in the development and progression of breast cancer. Octinoxate affects other hormone systems as well. For instance, it reduces thyroid hormones in blood serum. [8] Thyroid hormones are critical for metabolic functions in the body including mammary gland development. Octinoxate exposure has also been found to alter the reproductive systems of female offspring, with significantly lowered hormone (estradiol and progesterone) levels, [1] which is associated with infertility and miscarriages. In males, there is a reduction in sperm count at all dose levels. [1]

>Reproductive organs and development toxicity:
Numerous studies have reported that octinoxate exhibits antiandrogenic activity, which is linked to harmful effects on reproductive organ development in male and female fetuses exposed in utero. These effects can be further passed onto their offspring. Moreover, octinoxate alters the weight and structure of reproductive organs in male and female rats.[9]

*Vulnerable Populations:
Babies & Children, Pregnant Women, Teenagers, Women of Color

*Regulations
Octinoxate is approved for use in cosmetics worldwide; the maximum concentration in ready-for-use preparations varies according to local legislation. [3] According to the U.S. FDA, the recommended use level is up to 7.5 percent. [4]

Souce: https://www.safecosmetics.org/chemicals/octinoxate/

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